The product: After identifying a gap in the market for a true regenerative medicine membrane, Orthocell developed CelGro™, a non-reactive resorbable membrane that promotes enhanced bone and soft tissue repair. This next-generation collagen-based scaffold is manufactured with Orthocell’s patented SMRT™ tissue engineering process. It is designed to produce a pure collagen scaffold and is devoid of reactive DNA, lipids and cell fragments, but preserves the collagen bundles and mechanical strength without crosslinking.
How it works: The barrier membrane’s exceptional regenerative properties are directly related to its composition and structure. The porous bilayer structure is bio-conductive, promoting cellular migration, adhesion and proliferation. Its pure Type I collagen bundles are osteoconductive and integrate to assist with remodeling the regenerating tissue into mature bone. The absorption rate in vivo provides optimal time for the formation of new bone while maintaining the barrier function to exclude the gingival epithelia.
Clinical results: In a case series of 20 patients who received guided bone regeneration (GBR) with CelGro™, investigators observed mature, corticalized bone with fully integrated graft material in all patients within three to five months (Fig. 1).